Posted by Elroy on March 12, 2005, at 14:29:35
In reply to RE: LYRICA and the USA, posted by gromit on March 11, 2005, at 22:58:59
According to my research Rick you should be fine. The cut-off level (for becoming an MOA Inhibitor with the dietary restrictions) is 15 - 20 mg. or higher. A couple of researchers have even indicated that the cut-off level could be as high as 30mg (or at least inferred that), but I would stay safe and keep things at the 15mg and under level.
QUOTE "At doses of 10-15mg/day or less for humans, deprenyl is a selective MAO-B inhibitor. MAO-A enzymes break down serotonin and noradrenalin, while MAO-B enzymes break down dopamine and phenylethylamine (PEA). " END QUOTE
Have you tried it with the protocol of taking the amino acid DLPA (DL Phenylalanine) on an empty stomach about 30 minutes before taking the deprenyl?
As I (who am just a humble layman who reads a lot) understand it, the DL-Phenylalanine converts quite a bit into Tyrosine which converts quite a bit into L-Dopa which converts quite a bit into Dopamine which converts quite a bit into what used to be called Adrenalin (a term not so much used now as it apparently quickly breaks down into Norepinephrine and Epinephrine). What L-phenyalanine is not used in the above conversion process (if I have this right) is a direct precursor to phenylethylamine (PEA). PEA acts as an endogenous compound in the brain that promotes energy and elevates mood
QUOTE "A deficit of PEA is implicated in ADHD and depression while too much PEA might be a part of schizophrenia." END QUOTE
When administered with the deprenyl, PEA improves mood without developing tolerance. PEA alone has an extremely short half-life (the half-life of PEA is estimated at only 0.4 minutes), but when taken with deprenyl the PEA half-life is greatly extended... Also deprenyl itself apparently increases PEA levels significantly....
QUOTE: “ …deprenyl increases dopamine levels… by 40-70%, deprenyl increases PEA levels 1300 - 3500%! PEA is the preferred substrate for MAO-B, the MAO that deprenyl inhibits." END QUOTE
By the way, what's so great about this thing called PEA?
QUOTE: "Phenyl-ethyl-amine (PEA)... is indeed the great amphetamine of the romance stage of love. It makes us feel at least slightly euphoric and depresses appetite. " And also: "Among supplements, phenylalanine is known to increase PEA levels... The anti-aging drug DEPRENYL also raises PEA levels. With just the right dose of deprenyl, we see expanded life span in lab animals; with too much, lifespan shortens."
ALSO: "PEA or phenylethylamine (which speeds up the flow of information between nerve cells), DOPAMINE (the feel-good chemical)"
AND ALSO "In humans, too much PEA has been associated with psychiatric disorders (but certainly not depression). There is apparently just the right range of PEA that we need for optimal neurochemistry. Too much romance, deprenyl, or maybe even chocolate is like too much exercise — it is actually harmful."
END QUOTEFor much more info on deprenyl's very positive (low-dose) effects overall, see:
http://www.offshorepharmacy.net/ias-deprenylJS.htm
BTW, L-phenylalanine by itself (without the mirror D-version) can improve mood and relieve depression when orally administered alone and even more so deprenyl. (See: Birkmayer W, Riederer P, Linauer W, Knoll J. L-deprenyl plus L-phenylalanine in the treatment of depression. J Neural Transm. 1984;59(1):81-7.)
So if DLPA isn't working just right - or maybe too strongly, maybe too much jittery anxiety - one might want to try the L-version instead of the DL-version???
> >
> > Kara, plese consult a pharmacist before taking selegiline. My understanding is that it can be lethal to take Selegiline and tricyclics, of which doxepin is one. Also certain prescription pain relievers are to be avoided -Demerol being the only one that comes to mind.
> >
> > SELEGILINE IS NOT A SUPPLEMENT!!!!!!! It is a prescription drug and the same precautions should be practiced as with other pharmceuticals.
>
> I've been taking 10 mg selegiline with trazodone 25 mg for about 2 weeks now. I also take vicodin, officially for a torn rotator cuff but really as an AD, it doesn't help my pain much anymore. It does seem to make the vicodin more potent but maybe it's just my imagination.
>
> I researched this as much as I could, a lot of the technical stuff I don't understand, it seemed there might be a small risk but my doses are pretty low. Anyway I haven't keeled yet but YMMV.
>
>
> Rick
>
poster:Elroy
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050225/msgs/470082.html