Posted by Elroy on March 11, 2005, at 21:32:10
In reply to RE: LYRICA and the USA » Elroy, posted by KaraS on March 11, 2005, at 1:29:27
Couple of sites to check out concerning GABA.....
http://www.vcu-cme.org/gaba/gaba2_22.pdf
http://my.webmd.com/content/article/73/88950.htm
Did you say that you had tried Neurontin but had problems with it? Adverse side effects? Too swedating, maybe? The first two days on it - and the very first day was before I started the Selegiline combo - I had a ton of energy and vitality (so I can't credit that first day to the selegiline combo), but today there were two different times where I just couldn't keep my eyes open for anything!Some of the reviews that I've read have indicated that several people had the symptoms fade out after the first few days....
Trying to find an easy way to increase GABA levels in the brain. GABA - the amino acid - is really cheap when bought in bulk, but GABA as an amino acid ahs a very hard time crossing thru the brain's blood barrier.
See: http://www.raysahelian.com/gaba.html
QUOTE: GABA is made in the brain from the amino acid glutamate with the aid of vitamin B6. GABA is available as a supplement in vitamin stores, but taking it in pill form is not always an effective way to raise brain levels of this neurotransmitter because GABA cannot easily cross the blood-brain barrier. Companies are searching for ways to place GABA in an oil base in order to ease its entry across this barrier. END QUOTE
QUOTE: GABA pharmacology-what prospects for the future? Biochem Pharmacol. 2004 Oct 15;68(8):1537-40.
Following the recognition of GABA as an inhibitory neurotransmitter, the discovery of high affinity GABA uptake, and the characterisation of GABA receptors great progress has been made in developing GABA pharmacology. Tiagabide, the first marketed GABA uptake inhibitor may be followed by new and more selective uptake inhibitors. Knowledge of the molecular pharmacology of GABA-A receptors, both synaptic and non-synaptic, may lead to improved anti-anxiety/anticonvulsant agents devoid of the sedative and dependence liabilities of earlier compounds and new hypnotics. Gaboxadol (THIP) is an example of a novel hypnotic that acts on GABA-A receptors by a non-benzodiazepine mechanism. Exploiting neurosteroid interactions with GABAergic mechanisms also holds much future promise. END QUOTEPossible modification that does easily cross the brain barrier?
http://www.antiaging-systems.net/picamilone-info.htm
http://www.horizonnutra.com/lpyro.html
http://www.thebullmagazine.com/magmain.php?issueID=4&pageID=65
Also, and this is interesting, but I definitely recall reading in a book on anxiety somewhere that we also have GABA receptors not only located in our brain, but in our stomach and chest areas... so maybe oral consumption of GABA does have some non brain related beneficial actions?
poster:Elroy
thread:452259
URL: http://www.dr-bob.org/babble/alter/20050225/msgs/469870.html