Posted by Larry Hoover on November 2, 2004, at 9:03:40
In reply to Re: Vitamin D » Larry Hoover, posted by JLx on November 1, 2004, at 17:32:49
> I was so intrigued by your 4000 IU recommendation that I did a lot of looking around and started a board on Vit D and depression. http://www.dr-bob.org/babble/alter/20041022/msgs/410247.html I hope you will check it out. Maybe you can answer my question on there as to why sunlight Vit D isn't toxic, but supplemental is -- assuming it is -- when it's the same kind, or is it?
>
> JLYou're good. Scary good. I'll just make a summary statement here, but the 4000 IU recommendation is based on solid research, and it's quite a new finding. It takes a while for the facts to filter through into what we know.
I think the oral toxicity of vitamin D is related to the bolus effect. What that is is the huge serum concentration spike that comes from uptake across the gut wall. Vitamin D synthesized in skin trickles out into the blood, via diffusion. The total amount made from acute sun exposure is not just suddenly dumped into the blood. It's the essence of a timed-release vitamin D repository.
Did you catch note of the positive effects arising from a single oral dose of 100,000 IU? I recall seeing that last night, as I was skimming. It gives one pause, with respect to oral toxicity.
Lar
poster:Larry Hoover
thread:359642
URL: http://www.dr-bob.org/babble/alter/20041022/msgs/410535.html