Posted by tealady on September 20, 2003, at 9:06:22
In reply to Re: amalgam » Kacy, posted by Larry Hoover on September 20, 2003, at 7:20:09
Lar,
>Don't overthink it, OK?
Well how's this...I did look up the dental filling, Citanest Plain.
http://www.dentsplypharma.com/Package%20Inserts/Citanest%20PI.pdfIt doesn't sound too good.
My reactions were..not enough numbing..late onset of numbing (not in the PDF)..got tissue numbing 1/4 hr to 3 1/2 hrs after injection. (max level about 1 1/2 hrs after injection)..so didn't work real well
About 4 hrs later..fatigue developing into a migraine for about 3 days(mild)..coming out of this depressed and emotional.
At the time, and the next few days, I thought I was getting asthma as could only take half breaths. I tried deep breathing and found I couldn't do it..would feel I needed more oxygen and start gasping for air, or splutter and wheeze a bit, and also 'tingling' increased....didn't notice any "blueness " though.
But I was taking VitC in large doses ..like 4g 2 times a day, with magnesium..and other vits, and I read the treatment is VitC..so I was wondering if perhaps I do have a mild reaction to methaeglobulin..
I seem to go "reasonable" on xylocaine with o.o1 mg/ml adrenaline (lindocaine)
http://www.dentsplypharma.com/Package%20Inserts/Xylocaine%20PI.pdf
which appears similar...although sometimes get a headache, never as depressed and no trouble breathing, tingling etcBoth Prilocaine and Lidocaine say "
CONTRAINDICATIONS
Prilocaine is contraindicated in patients with a known history of hypersensitivity to local anesthetics of the amide
type and in those rare patients with congenital or idiopathic methemoglobinemia"
-------------------"Hydrolysis of prilocaine by amidases yields ortho-touluidine and N-propylanine. Both of these compounds may undergo ring hydroxylation.
O-toluidine has been found to produce methaemoglobulin"So I tried to see if I could learn anything from this. I tried searching for methaemoglobulin..I did come across a photo of red/blue feet from it..now I get that from B12(hydrocobalamine) , and hands too..used to go a deep purple color and really tingle, with each needle has been lessening in effect..about 2 years now..also a slightly less reaction from Methylcobalamin sublinguals. I've showed this to docs and they never could figure it out...so now I wonder
http://courses.nus.edu.sg/course/patleesh/ha/drugs.htm..except that would be a very washed out photo of my feet..mine went a real deep shade, and hands
So I was wondering where the break was ..and if I could put this to use ..like perhaps taking NADH (as you suggested) might bypass a missing enzyme?http://www.genome.ad.jp/dbget-bin/www_bget?path:hsa00380 Tryptophan metabolism
http://www.genome.ad.jp/dbget-bin/show_pathway?hsa00760+55191 Nicotinate and nicotinamide metabolism - Homo sapiens
http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/6/2/4.html
IUBMB Enzyme Nomenclature
EC 1.6.2.4
Common name: NADPH-ferrihemoprotein reductaseReaction: NADPH2 + 2 ferricytochrome = NADP + 2 ferrocytochrome
Other name(s): NADP-cytochrome reductase; TPNH2 cytochrome c reductase; ferrihemoprotein P-450 reductase; reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate); NADPH-cytochrome c reductase; TPNH-cytochrome c reductase; dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase; reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase; cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent); NADPH-cytochrome c oxidoreductase; NADPH-ferricytochrome c oxidoreductase; NADPH-dependent cytochrome c reductase; NADP-cytochrome c reductase; FAD-cytochrome c reductase; NADPH-cytochrome p-450 reductase; aldehyde reductase (NADPH-dependent)
Systematic name: NADPH:ferrihemoprotein oxidoreductase
-----------
I forget now where I got with this..but I couldn't find it in any pathways.
Don't overthink it, OK?>Just wanted you to know I did appreciate your replies and have been thinking, was just a bit brain fogged to give reasoned replies to all of them...but I will!
Not sure on any of this but hey I wouldn't want to give a standard boring excuse.....
Jan
poster:tealady
thread:259730
URL: http://www.dr-bob.org/babble/alter/20030903/msgs/261905.html