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Re: AD used for sleep? undopaminergic

Posted by linkadge on July 15, 2020, at 14:10:41

In reply to Re: AD used for sleep?, posted by undopaminergic on July 10, 2020, at 12:01:11

>It's not a real switch to mania, it's just >temporary, till it wears off.

This probably depends on the individual's course of bipolar. For example, for some, loss of sleep is the trigger to induce a switch to mania. Once an actual 'manic episode' (vs. say a manic reaction) is induced, it may not subside once the drug wears off.

In a lab dish, cultured brain neuronal cells from bipolar patients are oversensitive to stimuli. They can then continue firing erratically once that stimulus is removed. Elevated dopamine can also disturb the brains circadian rhythm. Stimulating D2 receptors increases GSK3 which can lengthen the wake phase. In a true bipolar patient (not drug induced bipolar III) this may not instantly switch back.

Linkadge


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URL: http://www.dr-bob.org/babble/20200711/msgs/1111274.html