Psycho-Babble Medication | about biological treatments | Framed
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Re: AD used for sleep?

Posted by undopaminergic on July 17, 2020, at 5:46:14

In reply to Re: AD used for sleep? undopaminergic, posted by linkadge on July 15, 2020, at 14:10:41

> >It's not a real switch to mania, it's just >temporary, till it wears off.
> This probably depends on the individual's course of bipolar. For example, for some, loss of sleep is the trigger to induce a switch to mania.

Yes, sleep deprivation can induce a manic switch, or perhaps it is rather the other way around: reduced need for sleep is a sign of onsetting (hypo)mania. Moreover, sleep deprivation can induce psychosis.

But in my experience, despite a reduced need for sleep under stimulants, there is no switch, now matter how long you stay up. It is as if the stimulants have a stabilising effect.

And as you said, it varies between individuals.

> Once an actual 'manic episode' (vs. say a manic reaction) is induced, it may not subside once the drug wears off.

That is absolutely true if it is indeed a switch. I'm suggesting that it normally isn't.

> In a lab dish, cultured brain neuronal cells from bipolar patients are oversensitive to stimuli. They can then continue firing erratically once that stimulus is removed.

That is interesting, but in my experience, (classic) (hypo)mania is a pretty smooth experience, and does not feel "erratic", except perhaps if you regard the impulsiveness as such.

> Elevated dopamine can also disturb the brains circadian rhythm. Stimulating D2 receptors increases GSK3 which can lengthen the wake phase. In a true bipolar patient (not drug induced bipolar III) this may not instantly switch back.

As far as I'm aware, elevated dopamine (in some parts of the brain) stimulates wakefulness directly. I don't know whether GSK3 is part of the mechanism. This article suggests Fos may be involved:





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