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Re: AD used for sleep?

Posted by undopaminergic on July 17, 2020, at 5:46:14

In reply to Re: AD used for sleep? undopaminergic, posted by linkadge on July 15, 2020, at 14:10:41

> >It's not a real switch to mania, it's just >temporary, till it wears off.
>
> This probably depends on the individual's course of bipolar. For example, for some, loss of sleep is the trigger to induce a switch to mania.
>

Yes, sleep deprivation can induce a manic switch, or perhaps it is rather the other way around: reduced need for sleep is a sign of onsetting (hypo)mania. Moreover, sleep deprivation can induce psychosis.

But in my experience, despite a reduced need for sleep under stimulants, there is no switch, now matter how long you stay up. It is as if the stimulants have a stabilising effect.

And as you said, it varies between individuals.

> Once an actual 'manic episode' (vs. say a manic reaction) is induced, it may not subside once the drug wears off.
>

That is absolutely true if it is indeed a switch. I'm suggesting that it normally isn't.

> In a lab dish, cultured brain neuronal cells from bipolar patients are oversensitive to stimuli. They can then continue firing erratically once that stimulus is removed.
>

That is interesting, but in my experience, (classic) (hypo)mania is a pretty smooth experience, and does not feel "erratic", except perhaps if you regard the impulsiveness as such.

> Elevated dopamine can also disturb the brains circadian rhythm. Stimulating D2 receptors increases GSK3 which can lengthen the wake phase. In a true bipolar patient (not drug induced bipolar III) this may not instantly switch back.
>

As far as I'm aware, elevated dopamine (in some parts of the brain) stimulates wakefulness directly. I don't know whether GSK3 is part of the mechanism. This article suggests Fos may be involved:
https://pubmed.ncbi.nlm.nih.gov/16399687/

-undopaminergic


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