Posted by undopaminergic on July 17, 2020, at 5:46:14
In reply to Re: AD used for sleep? » undopaminergic, posted by linkadge on July 15, 2020, at 14:10:41
> >It's not a real switch to mania, it's just >temporary, till it wears off.
>
> This probably depends on the individual's course of bipolar. For example, for some, loss of sleep is the trigger to induce a switch to mania.
>Yes, sleep deprivation can induce a manic switch, or perhaps it is rather the other way around: reduced need for sleep is a sign of onsetting (hypo)mania. Moreover, sleep deprivation can induce psychosis.
But in my experience, despite a reduced need for sleep under stimulants, there is no switch, now matter how long you stay up. It is as if the stimulants have a stabilising effect.
And as you said, it varies between individuals.
> Once an actual 'manic episode' (vs. say a manic reaction) is induced, it may not subside once the drug wears off.
>That is absolutely true if it is indeed a switch. I'm suggesting that it normally isn't.
> In a lab dish, cultured brain neuronal cells from bipolar patients are oversensitive to stimuli. They can then continue firing erratically once that stimulus is removed.
>That is interesting, but in my experience, (classic) (hypo)mania is a pretty smooth experience, and does not feel "erratic", except perhaps if you regard the impulsiveness as such.
> Elevated dopamine can also disturb the brains circadian rhythm. Stimulating D2 receptors increases GSK3 which can lengthen the wake phase. In a true bipolar patient (not drug induced bipolar III) this may not instantly switch back.
>As far as I'm aware, elevated dopamine (in some parts of the brain) stimulates wakefulness directly. I don't know whether GSK3 is part of the mechanism. This article suggests Fos may be involved:
https://pubmed.ncbi.nlm.nih.gov/16399687/-undopaminergic
poster:undopaminergic
thread:1111131
URL: http://www.dr-bob.org/babble/20200711/msgs/1111282.html