Posted by SLS on July 14, 2020, at 0:57:27
In reply to Re: Trinellix feel like an SSRI?, posted by SLS on July 13, 2020, at 16:22:27
Also, I don't think it's a good idea to be constantly jumping up and down in dosage. For the most part, biological systems like stability and homeostasis. "Pulsing" antidepressants sometimes leads to treament resistance - at least to that drug.
There was a term that emerged in the 1990s, but I haven't heard it used very often. "Treatment discontinuation-induced treatment refractoriness". Robert Post first used it to describe what he saw in his patients who stopped taking lithium. This happened with a friend of mine. She responded very well to lithium monotherapy for years to treat her depression (possibly bipolar). She functioned well as a ER nurse, having graduated from UNC Chapel Hill. When she moved across the country, her new psychiatrist told her that it was time to discontinue the lithium. Why? I have no idea. Three weeks after her last dose, she relapsed into a severe anergic and anhedonic depression. As you guessed, reintroducing the lithium was useless. The antidepressant response could not be recaptured. "Lithium-discontinued induced lithium refractoriness". She has been going around the pharmacological merry-go-round for decades with very little relief. I wish I could convince her to go on Nardil along with either Wellbutrin or a TCA.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1110801
URL: http://www.dr-bob.org/babble/20200711/msgs/1111265.html