Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Trinellix feel like an SSRI?

Posted by SLS on July 14, 2020, at 0:57:27

In reply to Re: Trinellix feel like an SSRI?, posted by SLS on July 13, 2020, at 16:22:27

Also, I don't think it's a good idea to be constantly jumping up and down in dosage. For the most part, biological systems like stability and homeostasis. "Pulsing" antidepressants sometimes leads to treament resistance - at least to that drug.

There was a term that emerged in the 1990s, but I haven't heard it used very often. "Treatment discontinuation-induced treatment refractoriness". Robert Post first used it to describe what he saw in his patients who stopped taking lithium. This happened with a friend of mine. She responded very well to lithium monotherapy for years to treat her depression (possibly bipolar). She functioned well as a ER nurse, having graduated from UNC Chapel Hill. When she moved across the country, her new psychiatrist told her that it was time to discontinue the lithium. Why? I have no idea. Three weeks after her last dose, she relapsed into a severe anergic and anhedonic depression. As you guessed, reintroducing the lithium was useless. The antidepressant response could not be recaptured. "Lithium-discontinued induced lithium refractoriness". She has been going around the pharmacological merry-go-round for decades with very little relief. I wish I could convince her to go on Nardil along with either Wellbutrin or a TCA.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:1110801