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Re: Amitriptyline and percentages of SERT blockade SLS

Posted by undopaminergic on May 9, 2020, at 12:16:09

In reply to Re: Amitriptyline and percentages of SERT blockade undopaminergic, posted by SLS on May 9, 2020, at 11:24:53

> Combining an irreversible MAOI that inhibits MAO-A with a potent serotonin reuptake inhibitor is the most dangerous combination of antidepressants that I can think of. I know this from personal experience (Parnate + single a small dose of Effexor).
>

I agree. I was just saying the dose makes the poison. How dangerous is 5 mg sertraline when added to a fully MAO-inhibitory regimen?

> Is tobacco a potent inhibitor of MAO-A?

https://www.ncbi.nlm.nih.gov/pubmed/11343627
Cite: "Smokers have 30-40 % lower MAOB and 20-30 % lower MAOA activity than non-smokers."

-undopaminergic


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