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Re: Amitriptyline and percentages of SERT blockade undopaminergic

Posted by linkadge on April 11, 2020, at 12:26:10

In reply to Re: Amitriptyline and percentages of SERT blockade, posted by undopaminergic on April 11, 2020, at 12:00:50

>What about cocaine? It is a SRI for sure, but I >never heard of serotonin syndrome from it. Perhaps >it is self-limiting due to coke's short half-life?

True. And I'm sure there are tons of people that smoke (MAOI) and use cocaine. Although, I have read about case reports where adding methylphenidate to a particular regime has resulted in serotonin syndrome. My theory for this is that, when serotonin reuptake inhibition gets high, there is evidence that the dopamine transporter can begin to take up serotonin and that this might be the causative mechanism.

"They found that higher serotonin concentrations caused by SSRIs can "trick" transporters of another key neurotransmitter, dopamine, into retrieving serotonin into dopamine vesicles. "

So, perhaps adding a dopamine reuptake inhibitor to an SSRI could actually further augment serotonin levels.





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