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Re: Amitriptyline and percentages of SERT blockade Skeletor

Posted by SLS on May 9, 2020, at 11:35:50

In reply to Amitriptyline and percentages of SERT blockade, posted by Skeletor on April 10, 2020, at 12:12:07

> Can you reach clinically significant SERT blockade [~ 80%] with Amitriptyline?

I can't answer your question. However, I would mention that Nardil 45mg/day + amitriptyline 150mg/day did not cause serotonin syndrome. Perhaps the dosage of Nardil was too low to produce a reaction. With a higher dosage, I had a reaction when imipramine was chosen to combine with it. Muscle rigidity was the most prominent symptom.


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