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Re: Starting Cocaine XR next week

Posted by undopaminergic on April 24, 2020, at 3:07:04

In reply to Re: Starting Cocaine XR next week Lamdage22, posted by linkadge on April 23, 2020, at 17:19:54

> >I think that getting high is just not a solution. >You just need to take a look at the people begging >for money at trainstations. Of course you >temporarily feel better. That is what illegal drugs >do.
> Maybe. Maybe not. How many doctors would have said that depressives were 'just getting high' on ketamine and then dismissed their reports?
> But, would cocaine's effect still only be temporary if you took it in lower doses, in a controlled release fashion?

Temporary, yes, just like other drugs. However, in an XR formulation, of course the duration of action would be much longer. Even without XR, the duration of an oral dose can be longer than an hour.

> Some studies suggest that what really makes cocaine abusable is the rate at which it occupies the dopamine transporter. I.e. snorting it gives a massive, sudden inhibition of DAT resulting in a huge surge of dopamine.

Yes. Nora Volkow suggested the rapid rise of dopamine (DA) with IV cocaine and methylphenidate mimics "phasic" DA firing rather than increased "tonic" concentration (of synaptic DA). "Phasic" is the kind of DAergic rise that takes place in "natural" dopamine release in response to reward (or reward-seeking). "Tonic" is the "background" concentration of DA.

Increased tonic DA still feels good, but there is none of the "rush" produced by phasic DA rise.

> The only difference between recreational cocaine and theaputic Ritalin, is perhaps dose. The same thing goes for recreational meth and therapeutic Dexedrine.

Roughly, yes, unless you meant Desoxyn. From what I understand, meth-amphetamine has some differences from "regular" amphetamine in terms of its relative potencies in releasing the different monoamines. IIRC serotonin and dopamine are relatively higher with meth. Meth also has a much longer half-life.





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