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Re: Starting Cocaine XR next week

Posted by undopaminergic on May 3, 2020, at 3:52:53

In reply to Re: Starting Cocaine XR next week rjlockhart37, posted by linkadge on May 1, 2020, at 18:00:41

> Many of the cardiovascular issues are likely caused by a large surge in norepinephrine via reuptake inhibition and/or release. Some of it could be related to sodium channel blockade at high doses.

Probably not -- I read that all the -caine local anaesthetics, except for cocaine, induce vasodilation.

I think it's the noradrenaline. From what I read, it often appears that cocaine is a particularly strong noradrenaline reuptake inhibitor, in comparison with eg. methylphenidate. Maybe the dose-response curve does *not* flatten at higher doses.





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