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Re: Revisiting Naltrexone for Depression

Posted by Hugh on March 8, 2020, at 15:36:09

In reply to Revisiting Naltrexone for Depression, posted by bleauberry on March 6, 2020, at 21:09:30

You don't need to go to a compounding pharmacy for low-dose naltrexone. Just take a 50 mg tablet of naltrexone and drop it into 50 ml of distilled water. After 30 minutes, stir it thoroughly, and you're all set with liquid LDN. It will keep in the refrigerator for over a month. Start with a dose of 1 mg, taken at bedtime. Increase your dose gradually over the next several weeks. The maximum dose of LDN is 4.5 mg.

If low-dose naltrexone doesn't have the desired effect on you, it might be worth your while to try an even lower dose of it. If that doesn't help, then go even lower. In fact, the lower the dose of naltrexone, the more effective it might be. The following quote is from

"Cotreatment with ultra-low-dose naltrexone at 16.7, 20, or 25 ng/kg, but not at 10 or 200 ng/kg, induced a significant CPP after this 2-h delay. This finding implies that, whereas the rewarding effects of morphine have dissipated by 120 min postinjection, ultra-low-dose naltrexone may extend this effect."

In other words, an extremely low dose of naltrexone enhanced the effects of morphine, and prevented tolerance to it from developing. And it prevented dependence and addiction from developing. A higher, but still tiny, dose of naltrexone didn't have these beneficial effects.

Even if you're not taking opioids, you might benefit from taking ultra-low-dose naltrexone, since we all have naturally occurring opioids -- endorphins. An extremely low dose of naltrexone, taken every day, might improve your brain's response to your naturally occurring endorphins.

So if you aren't helped by 1.5 to 4.5 milligrams of naltrexone, try lowering your dose to micrograms. If that doesn't help, lower your dose to nanograms. If that doesn't help, lower it to picograms. Other than the naltrexone, all you need is distilled water to dilute it with and a calculator.




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