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Re: Revisiting Naltrexone for Depression

Posted by undopaminergic on March 7, 2020, at 9:39:20

In reply to Re: Revisiting Naltrexone for Depression, posted by linkadge on March 7, 2020, at 6:08:40

> Naltrexone is also a potent kappa opioid antagonist.

Right, and so is buprenorphine (Subutex, Suboxone, Temgesic, Buprenex). In combination with methylphenidate (Concerta), it (Temgesic) was the best combination I've ever been on, and I only stopped it because they stopped prescribing.

> Activation of kappa receptors causes dysphoria. Stress increases dynorphin which activates the kappa opioid receptors which leads to diminished dopamine release. Dynorphin is also increased by chronic drug / alcohol abuse.

Yes, and in addition, it seems to be one of the mechanisms causing tolerance to stimulants, at least cocaine, but probably methylphenidate too. I'm not sure, but I wouldn't be surprised if it (dynorphin) is also involved in tolerance to other drugs.





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