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Re: Revisiting Naltrexone for Depression

Posted by linkadge on March 7, 2020, at 6:08:40

In reply to Revisiting Naltrexone for Depression, posted by bleauberry on March 6, 2020, at 21:09:30

Naltrexone is also a potent kappa opioid antagonist. Activation of kappa receptors causes dysphoria. Stress increases dynorphin which activates the kappa opioid receptors which leads to diminished dopamine release. Dynorphin is also increased by chronic drug / alcohol abuse.

Anyhow, naltrexone may be working (in part) via this mechanism.





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