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Re: memantine -- mania / Alzheimer's SLS

Posted by undopaminergic on March 7, 2020, at 22:35:48

In reply to Re: Question..please help re: alzheimer's, depression undopaminergic, posted by SLS on March 7, 2020, at 17:39:27

> Hi.

Hi.

[Re. memantine]

> > I felt great on it, with sufficient doses. Unfortunately, it actually produced mania, and the ending was not happy. Think self-destructive behaviour and hospitalisation.
>
> How much did you take?

First time I tried it, I took 5 or 10 mg, and it made me feel weird. I actually gave up on it. Next time, I was going to exploit the "feeling weird" effect, and I tried 20 mg, but instead, a got a hypomanic reaction. Then I was unable get more of it, until I bought 100 grams of 99%+ lab tested memantine powder, and I experimented with doses of 20 mg of so; I was afraid to go higher because I was worried about "Olney's lesions". This dose was insufficient to achieve any kind of worthwhile effect, so I gave up on it again.

Then, later I was apparently in a more reckless/courageous/desperate state (though not manic), and I used 60, maybe up to 80 mg -- as needed -- and I was hoping for the best with regard to the lesions. That's when I got the manic effect. The self-destructive behaviour included taking several 1000 mg of memantine powder, in an attempt to produce Olney's lesions and completely obliterate my retrosplenial cortex, or something like that. I remember lying on the floor performing purposeless movements with one of my arms, and I just couldn't motivate myself to stop, because I was catatonic. I apparently kept up these purposeless movements indefinitely, and I am told they found me in a puddle of sweat. I understand I had rhabdomyolysis, and I was close to serious kidney damage. I almost died, because it was more or less accidental that they found me in time and called for the ambulance. I was taken to hospital for intensive care. From my period at the "somatic" hospital, I only barely remember a beautiful blond nurse I was somehow teasing sexually (think kinky nurse fantasies). When I started remembering normally again, I was in the psych ward. Unsurprisingly, I went back into a depressive state.

My parents got rid of my memantine, and I have not used it again, though I would be willing to try -- with great caution.

Mania is to be taken seriously, I have realised as of late. Especially the mixed mania. I had classic (euphoric) mania, but a discussion I had with my parents made me angry, and I decided enough was enough and so I did the self-destructive stuff. That's how easily a classic mania may transition into mixed.

A friend later informed me that memantine does not produce Olney's lesions... otherwise, I suppose I would have serious brain damage today. I am almost certainly the world-record holder in the category of greatest dose of memantine taken.

I'm pleased that I've been developing more insight lately regarding such things as mania and psychosis. Trimipramine is the most effective antipsychotic for me, much more effective than even clozapine.

> My mother was diagnosed with Alzheimer's. Nothing really works, from what I've read. I don't think that donepezil and memantine are as effective as doctors once convinced themselves they were.
>

Agreed.

> The only drug that might have some value is lithium when taken in small amounts. I doubt more than 150 mg/day of lithium carbonate is necessary. I just bought some lithium orotate for Mom. I couldn't get her doctor to prescribe lithium, so that was the best I could come up with. I got the Weyland brand lithium orotate that delivers 20mg of elemental lithium.
>

That should be more than enough.

-undopaminergic


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