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Re: New US made Marplan now available... sigismund

Posted by SLS on February 2, 2020, at 22:05:37

In reply to Re: New US made Marplan now available... SLS, posted by sigismund on January 27, 2020, at 15:29:37

> >The other thing is that I always find myself switching back to Parnate, although I can't remember why right now.
> In spite of the mood brightening of Nardil you felt less stable on it?

I can't remember exactly why I always become unhappy with Nardil and end up going back on Parnate. I am not particularly greedy. I wouldn't be 100% happy without a 100% improvement, but I'll take 50%. I don't think I'm unrealistic as to what to expect. I have my memories of improvements and remissions to help me gauge the magnitude of my response to treatment. I am sure that I'm not chasing a Nardil hypomania. I've been playing with Trintellix and Effexor for two years, - using Parnate as an intermission. Trintellix and Effexor both tickled my brain in a way that produced a brief awakening. Not only did I have the energy to do things, but I had a strong desire to do things. It felt good to do things. Doing things was rewarding. My mind became active and sharp. The assertiveness and self-confidence that appeared was pretty cool, too. Food tasted better, colors were more vivid, and music was magical. The problem is that these responses occurred only when I increased or decreased the dosage. Staying at the same dosage doesn't work. This is also what I experience with MAOIs, but not with TCAs. Each of these brief responses lasted for 2-4 days. Tickling the brain? Moving back and forth through a zone? I don't know. After 6 months of cycling between hopeful improvements and crushing relapses, I decided that it was time to move on.

When it works, Nardil has mood-brightening and motivational properties that Parnate lacks (for me). My thoughts are clearer and I am more sociable. Despite this, I always end up asking my doctor to switch me to Parnate. If Nardil had given me a stable 50% improvement, I doubt that I would have wanted to stop taking it so many times. My doctor agreed that it was worth trying Marplan again, since I was so impatient and impulsive the last time. He also came up with two interesting ideas. I will add Buspar now and then see what happens with Marplan. If we get stuck, he wants to switch me from nortriptyline (Pamelor) to trimipramine (Surmontil). He had one patient who was not responding adequately to taking a combination of Parnate and nortriptyline. She did very well once he switched her to trimimpramine.

We'll see.

I'm always glad to see you, but I never think to ask how you are.

How are you?


- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw




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