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Re: ..::: Parnate augmentation? (Nardil other meds) rose45

Posted by undopaminergic on December 21, 2019, at 9:12:51

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by rose45 on December 21, 2019, at 4:32:16

> > > augmenting with low dose olanzapine - worked for me
...
> > > ROSE what were you effects were you seeking augment with the olanzapine: mood boost or stabilization? Also wondering how long it took for you.

> Sorry for the delay in replying porkpie hat. Ive only just seen your post. I had decreased the parnate, because I was feeling better and thought id be ok on a lower dose - and it just stopped working altogether even when I then increased it back up to 40mg per day. However, after a couple of weeks on olanzapine, it started working again! A total miracle ! I wish I could understand the chemistry of it, but the main thing is that parnate is now working even better than before (I was previously on 30mg).
>
>

This goes to show, that there is a lot we still have to figure out about neurobiology. To me it is counter-intuitive that olanzapine would help for depression. Then again, olanzapine is more than just a dopamine-antagonist, so there are several mechanisms that could be at play.

-undopaminergic


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