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Re: ..::: Parnate augmentation? (Nardil other meds) rose45

Posted by undopaminergic on December 21, 2019, at 9:12:51

In reply to Re: ..::: Parnate augmentation? (Nardil other meds), posted by rose45 on December 21, 2019, at 4:32:16

> > > augmenting with low dose olanzapine - worked for me
> > > ROSE what were you effects were you seeking augment with the olanzapine: mood boost or stabilization? Also wondering how long it took for you.

> Sorry for the delay in replying porkpie hat. Ive only just seen your post. I had decreased the parnate, because I was feeling better and thought id be ok on a lower dose - and it just stopped working altogether even when I then increased it back up to 40mg per day. However, after a couple of weeks on olanzapine, it started working again! A total miracle ! I wish I could understand the chemistry of it, but the main thing is that parnate is now working even better than before (I was previously on 30mg).

This goes to show, that there is a lot we still have to figure out about neurobiology. To me it is counter-intuitive that olanzapine would help for depression. Then again, olanzapine is more than just a dopamine-antagonist, so there are several mechanisms that could be at play.





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