Posted by pedr on July 5, 2019, at 10:53:42
In reply to Re: Spravato (esketamine), posted by Ruuudy on July 2, 2019, at 15:25:47
Thanks for the update Rudy. How is it faring when you're not under its immediate effects e.g. in between doses? Has it lifted your mood overall?
BTW I saw this https://www.psychologytoday.com/us/blog/evolutionary-psychiatry/201907/esketamine-depression-new-fda-approval-new-controversy which was a good read, esp. about discontinuation :
"JAMA Psychiatry also released a paper earlier this month that looked at longer-term treatment with esketamine. This study took 297 patients whose depression responded to esketamine + antidepressant and enrolled them in a randomized discontinuation phase after 16 weeks of treatment. Half continued with esketamine + antidepressant, the other half a placebo nasal spray and antidepressant, and were followed for about two years. Here the differences got quite significant: Continuing esketamine decreased risk of relapse of depression by 50-70% compared to placebo. Half of the relapses occurred in the first four weeks after stopping esketamine."
Pete
I love the smell of Abilify in the morning. The smell, you know that chemical smell. Smells like victory. Some day this war's gonna end...
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Atypical Depression, OCD, IBS-C, GERD since '96
poster:pedr
thread:1104865
URL: http://www.dr-bob.org/babble/20190513/msgs/1105164.html