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Re: Spravato (esketamine) » Couleuvre

Posted by pedr on July 1, 2019, at 7:17:02

In reply to Re: Spravato (esketamine) » Ruuudy, posted by Couleuvre on July 1, 2019, at 4:14:23

> I've had a lot of lousy docs who are totally closed-minded about trying anything remotely different from the standard stuff, and since I don't live in a big city or anything, I feel *really* lucky to have found someone who really knows what he's doing and all that.

Same here. Unwilling to remotely step outside the rules. I'm highly, highly atypical and they just won't act accordingly. Extremely frustrating and, well, life-destroying really.

>
> The big trouble with IN administration is that the absorption is kind of unpredictable compared to other routes. I'm sorta wondering why they decided to go with it, because I think esketamine could be administered by several routes that would be more convenient for the patient than having to go to a clinic to get IV injections and more consistently absorbed than IN, so that you could generally expect that if dose X works well for a certain patient while minimising side effects, then you can have that patient keep taking dose X and assume that it will keep working and there won't be any big changes in side effects.

Yeah - what happens when you have a cold for example? surely that thicker layer of mucus inside your nose affects absorption. I don't get it either.

>
> So...anybody have any idea how expensive Spravato is?

From https://www.statnews.com/pharmalot/2019/03/22/antidepressants-cost-effective-johnson-and-johnson/ : "...which set a list price of $590 to $885 per treatment session, depending on dosing and number of sessions, which can vary by patient. The initial month of therapy can cost from $4,720 to $6,785

I.e. a mega bucketload.

Is it helping at all for your depression? You mentioned it helps very short term which is nice but the main point of it is to help in the days after dosing of course.

Thanks for your update.
Pete


I love the smell of Abilify in the morning. The smell, you know that chemical smell. Smells like victory. Some day this war's gonna end...
====
Atypical Depression, OCD, IBS-C, GERD since '96


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