Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Spravato (esketamine)

Posted by Couleuvre on June 15, 2019, at 16:24:10

In reply to Re: Spravato (esketamine), posted by Ruuudy on June 15, 2019, at 13:50:46

> Very similar experience to all the coke I did back in the heyday.
> Nah,,, I wouldn't be able to compare it to that 'cause I've never done an illegal drug in my life (that I know about). I've only experienced intoxication.
> But I can say it's a very similar experience to the conscious sedation I was put into for a pre-op procedure about 5 years ago. A feeling of like you are hoovering above your body watching and listening to the doctors & nurses as they work on you.
>
> Yesterday was my 2nd treatment.
> I still can't say I am feeling any benefit yet - I should state "mental benefit".
> I did notice the arthritic pain in my shoulder area was next to gone!

Ah yes, the "good old days." (You know you've gotten middle-aged when you start finding yourself telling "back in my day" stories! :-) )

I take intranasal esketamine, where you squirt it in your nose from one of those squirt bottles, like some OTC stuff (mostly cough/cold/decongestants, I think).
Are you getting it that way, or do you get the injections? I don't know if you can even get esketamine injections for depression here in Nowheresville (USA). I started taking it before the FDA approved it for depression, and I'm not sure if you could get the intranasal stuff from a regular pharmacy, either, though. It only just occurred to me that I should check with my doctor to find out if maybe I could since it would probably be less expensive. (I get it from a compounding pharmacy.)

It's not surprising it was similar to a "conscious sedation" experience, since it's also used for that. It's also considered a good choice for [general] anaesthesia when you don't have the equipment & stuff to monitor patients' breathing, since it doesn't cause a lot of respiratory depression like most anaesthetics.

As for the antidepressant effect...I think it's very good in the short term (my prescription is to take it as needed, up to 3x/week) but when I tried taking it on a regular basis it didn't really seem to help much and made me feel tired a lot. Plus I *really* don't like the way it smells!

I suspect the injection is a more intense experience than taking it intranasally. The way that they said to do it is take one squirt every 5 minutes (or so), five times. It's quite variable, I think that the absorption is not very consistent when you take it this way. Usually I just feel kind of dizzy in a weird way. Occasionally, though, it hardly seems to have much of an effect at all, while other times it's really kind of trippy and causes some feelings of numbness and stuff.

I too was sort of surprised to come back to PB after all these years and not find people talking a lot about this very different sort of new antidepressant. I'm particularly surprised that the FDA actually approved it: usually these days the researchers who are interested in something like this have a very hard time finding any drug companies that are interested in doing all the research to something like this because they don't think it would be profitable. I wonder how they managed it.


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Couleuvre thread:1104865
URL: http://www.dr-bob.org/babble/20190513/msgs/1104874.html