Posted by ed nieg on January 31, 2019, at 12:36:04
In reply to Re: Antipsychotic-Induced Anhedonia: Rare? » bleauberry, posted by pedr on January 31, 2019, at 11:21:12
> > You mentioned Pramipexole but I think that is a bad choice.
> >
> > It looks good on paper. Theoretically it should be a good dopaminergic substance. And it is. Just not for mood.
> >
> > My doctor says Ritalin is her most prescribed medication because it helps so many people with so many different symptoms. There is no way anyone could say that about Pramipexole.
> >
> > I've followed a few people who tried Pramipexole and none of them did well with it. Side effects are harsh, risks are high, and benefits low.
> >
> > What I have concluded is that just because something is "dopaminergic" really doesn't mean that much. The important thing is the mechanism of how dopamine is manipulated not the dopamine itself. But the mechanism orchestrating it.
>
> In a nutshell I also have extremely TRD with TR OCD and anhedonia. And IBS. And chronic pain. Yay. Anyway, I experienced the above - Pramipexole recently did absolutely nothing for me. And I also experienced the below:
>
> > Ritalin, Adderall, or Modafinil. In my opinion Ritalin is the most effective with the least side effects. Adderall is second. Modafinil is not as reliable but sometimes works magic when nothing else does.
>
> I.e. that only stimulants raise me out of anhedonia. Except that for me Adderall is #1. Isn't it weird that all of us experienced the same inconsistent response to Provigil? One day it's world-beating, the next, nothing. Same for Nuvigil for me as well. I wonder why it's like that.
>
> Right now I'm doing so-so (which means "extremely well" relative to my normal state) on Trintellix, Rexulti and 3x20mg Adderall. But when the Adderall wears off, I just SATW (State At The Wall) i.e. feel very anhedonic.
>
> Oh, w.r.t. getting prescribed Ritalin, simply fake up ADD symptoms. F*ck them. Inattentive ADD is symptomatically very similar to anhedonia IMO.
>
> FTR I've tried 60+ combos, ECT, dTMS, Ketamine, more. Psilocybin is next for me but I'm only going to do it with a guide present and I've *no idea* how to go about finding one.
>
> PeteTripping with a guide isn't all that important; I went on a solo hiking "trips" and although there were definitely bad parts it was overall a rejuvenating experience. Personally, I wouldn't like to have some stranger tainting my trip with hocus-pocus sh*t but that's just me I guess, and I also tend to be pretty solitary anyways. Also, you might want to add the med Ezogabine to your to-try list, seems very promising for anhedonic-spectrum mental illnesses. It's only available in clinical trials though which sucks. I do have bona fide ADD wuth anhedonia (whole mesocorticolimbic system is shot), but I've always been blocked by the great gloved hand of institutional morality that presumes everyone to be a salivating crack addict the instant they ask for stimulants.
poster:ed nieg
thread:1102982
URL: http://www.dr-bob.org/babble/20181024/msgs/1103072.html