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Re: Measuring Drugs Activity at Receptors » linkadge

Posted by SLS on July 2, 2016, at 11:36:45

In reply to Re: Measuring Drugs Activity at Receptors, posted by linkadge on July 2, 2016, at 9:02:00

> On paper, pimavanserin looks interesting. I currently take mirtazapine (mainly for sleep) however, it hits histamine pretty hard. It might be nice to try a more selective 5-ht2a/c antagonist, to see how it augments venlafaxine with possibly less sedation.

Adding some nortriptyline to venlafaxine would take care of the 5-HT2a/c receptor antagonism and promote more NE reuptake inhibition than what a low dosage of venlafaxine does.

Understanding that my treatment responses in the past have been modest at best, I was impressed with the combination of venlafaxine + nortripyline. This occurred at a dosage of 75 mg/day of nortriptyline. We now know that I need 150 mg/day. For me, should I need to jettison Parnate, the first thing I would try would be a combination of venlafaxine 300 mg/day + nortriptyline 150 mg/day.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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URL: http://www.dr-bob.org/babble/20160609/msgs/1090097.html