Posted by linkadge on July 2, 2016, at 8:41:05
In reply to Re: Measuring Drugs Activity at Receptors, posted by Hello321 on July 1, 2016, at 16:07:36
Yeah, lower Ki means higher receptor affinity for a particular concentration of the drug (i.e. more active at that receptor).
The best site for Ki is:
http://kidbdev.med.unc.edu/databases/pdsp.php
However, one must also consider the factors affecting concentration of the drug namely:
- dose level
- half life
- absorption
- metabolismI.e. a drug with low absorbtion and / or high metabolism, would need a higher dose to achieve a certain concentration.
Linkadge
poster:linkadge
thread:1090060
URL: http://www.dr-bob.org/babble/20160609/msgs/1090087.html