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Re: Measuring Drugs Activity at Receptors » Hello321
Posted by TriedEveryMedication on July 1, 2016, at 13:01:24
In reply to Measuring Drugs Activity at Receptors, posted by Hello321 on July 1, 2016, at 10:30:25
Lower Ki number means stronger binding affinity. Single digit affinities or less are very strong.
here is a sampling of ki's for cyproheptadin
http://kidbdev.med.unc.edu/databases/pdsp.php?knowID=0&kiKey=&receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testLigandDD=&testFreeRadio=testFreeRadio&testLigand=Cyproheptadine&referenceDD=&reference=&KiGreater=&KiLess=&kiAllRadio=all&doQuery=Submit+Query
looks like the 2A range is averaging from 1.5 on up, depending on the study and what part of the brain they tested
2c: around 12.
Unfortunately, this DB doesn't have data for Pimavanserin
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URL: http://www.dr-bob.org/babble/20160609/msgs/1090064.html