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Re: Ketamine Nasal Spray SLS (Memantine study) » Deahoidar

Posted by SLS on November 30, 2015, at 7:12:29

In reply to Re: Ketamine Nasal Spray SLS (Memantine study) » SLS, posted by Deahoidar on November 29, 2015, at 22:40:27

> > > The article you mentioned appears to be a report of a single patient case study from some years ago. Is there anything more recent or more objective available? Thanks.
> >
> > I couldn't find anything, sorry.
> >
> >
> > - Scott
>
> Scott,
> I was interested by the potential of Memantine, so I searched a bit and came across this article in the American Journal of Psychiatry.
>
> "A Double-Blind, Placebo-Controlled Study of Memantine in the Treatment of Major Depression" http://dx.doi.org/10.1176/appi.ajp.163.1.153
>
> METHOD: In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (520 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary efficacy was assessed by performance on the Montgomery-Åsberg Depression Rating Scale (MADRS).
> RESULTS: The linear mixed models for total MADRS scores showed no treatment effect.
> CONCLUSIONS: In an 8-week trial, the low-to-moderate-affinity NMDA antagonist memantine in doses of 520 mg/day was not effective in the treatment of major depressive disorder.
>
> While not conclusive proof, it dampens my hopes for Memantine. Perhaps further study is warranted. Who knows.

I agree with the results and interpretation of the study. However, I know of no reason why mementine could not be used as an augmenter of drugs like Wellbutrin or Lamictal.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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