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Re: Ketamine Nasal Spray SLS (Memantine study) » SLS

Posted by Deahoidar on November 29, 2015, at 22:40:27

In reply to Re: Ketamine Nasal Spray SLS » Deahoidar, posted by SLS on November 22, 2015, at 21:15:30

> > The article you mentioned appears to be a report of a single patient case study from some years ago. Is there anything more recent or more objective available? Thanks.
>
> I couldn't find anything, sorry.
>
>
> - Scott

Scott,
I was interested by the potential of Memantine, so I searched a bit and came across this article in the American Journal of Psychiatry.

"A Double-Blind, Placebo-Controlled Study of Memantine in the Treatment of Major Depression" http://dx.doi.org/10.1176/appi.ajp.163.1.153

METHOD: In a double-blind, placebo-controlled study, 32 subjects with major depression were randomly assigned to receive memantine (520 mg/day) (N=16) or placebo (N=16) for 8 weeks. Primary efficacy was assessed by performance on the Montgomery-Åsberg Depression Rating Scale (MADRS).
RESULTS: The linear mixed models for total MADRS scores showed no treatment effect.
CONCLUSIONS: In an 8-week trial, the low-to-moderate-affinity NMDA antagonist memantine in doses of 520 mg/day was not effective in the treatment of major depressive disorder.

While not conclusive proof, it dampens my hopes for Memantine. Perhaps further study is warranted. Who knows.


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