Posted by SLS on November 22, 2015, at 6:45:47
In reply to Re: Ketamine Nasal Spray SLS » SLS, posted by Deahoidar on November 22, 2015, at 0:18:22
Hi Jim.
Nice to meet you.
I took intranasal ketamine for two weeks. There was not even a hint of improvement. I even tried taking the amount necessary to produce a very mild dissociative state. A good response to ketamine should take no longer than a week, and can take less than 48 hours.
I am probably met66met for BDNF. People with this uncommon genotype do very poorly with ketamine. People with the more common val66val variant do the best. Perhaps you are heterozygous - val66met, the genotype that produces a partial response.
http://bipolarnews.org/?p=2318
By the way, lithium is supposed to extend the response to ketamine.
The idea occurred to me to combine ketamine with memantine. They work on different areas of the NMDA receptor. You might want to look into it. I found this:
http://www.ncbi.nlm.nih.gov/pubmed/18197514
Unfortunately, no abstract is included. My concern would be the production of a synergistic effect to produce a dissociative state.
If you take too much ketamine all at once, it doesn't work. This would be a problem with I.V., but not likely with intranasal administration.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1083978
URL: http://www.dr-bob.org/babble/20151119/msgs/1084116.html