Posted by ed_uk2010 on January 24, 2015, at 17:40:01
In reply to Re: feeling like im out of options, posted by hello123 on January 24, 2015, at 17:02:25
> Am I wrong to make the assumption that id likely experience a very unpleasent emotional numbing effect from an MAOI that targets Serotonin, since thats all ive experienced from Reuptake Inhibitors that target Serotonin? Ive tried Lexapro, Zoloft, Prozac and Paxil. As well as SNRI's that id describe as making me feel numb and disconnected.
Yes, you are incorrect to assume that MAOIs 'feel' like SSRIs. Bear in mind, MAOIs do not affect serotonin in the same way as SSRIs. MAOIs make more serotonin available for release whereas SSRIs sort of trap serotonin in the synapse after it has been released. The effect on neurotransmission is not the same. Classical MAOIs also affect dopamine and NE directly. Dopamine is metabolised both by MAO-A and -B, not just B. Classical MAOIs therefore have a different effect on dopamine neurotransmission to low dose selegiline.
>Also, in the past ive responded very well to Adderall and somewhat well to Mirapex. Its like they put my good emotion at a 10, and do away with and Depression. but Chronic use at prescribed doses (never any abuse problems) of each only made my ability to feel pleasure worse.
I've never heard of anyone obtaining prolonged/sustained relief of depression from dopamine agonists like Mirapex. The benefit is seemingly transient.
Amphetamines like Adderall can provide a temporary boost but do not generally improve depression in the long run... and can readily make it worse.
I'd suggest Parnate for you since Nardil is more likely to be sedating. People respond differently though so you need to be open to trying both without too many preconceived ideas about what will work and why. Both drugs are proven treatments against severe depression.... naltrexone, oral low dose selegiline etc are not.
>Cyproheptadine was what helped me after this. ive read about Cypro's effects at Receptors, and came to the conclusion it likely helped by basically "disinhibitting" Dopamine, making it able to release in response to normally pleasurable experiences.
Possibly, but even the top neuroscientists don't understand all the details. You might perhaps find cyproheptadine of some use if you experience insomnia on an MAOI.
>Basically, ive figured i have a huge Dopamine problem.
The major neurotransmitters are all interconnected. You will not have a problem affecting dopamine in isolation. It's always worth bearing in mind that we do not really understand the cause/s of depressive illness at all.... we do have an idea what treatments may help though. Theories about what might be wrong with our brain function on a biochemical level are often highly simplistic ideas about a phenomenon more complex that we will ever understand.
I think you should speak to your doctor about stopping both selegiline and naltrexone, then starting Parnate after a short wash out. You will of course have to be careful about dietary and drug interactions. A lot of self-education is required.
poster:ed_uk2010
thread:1075467
URL: http://www.dr-bob.org/babble/20150102/msgs/1075478.html