Posted by ed_uk2010 on January 24, 2015, at 16:29:15
In reply to feeling like im out of options, posted by hello123 on January 24, 2015, at 16:02:14
Low doses of selegiline are fairly MAO-B selective. This strategy has not shown good efficacy in depression at all. As for high doses of oral selegiline... well, I think it would be a much better idea to take an MAOI proven to be of use in severe depression.
Moclobemide, a selective MAO-A inhibitor has, unlike low dose selegiline, shown efficacy in trials. Unfortunately, experience in treatment-resistant patients is that it doesn't work well in practice.
In all honesty, only classical non-selective MAOIs appear useful in treatment resistant depression. Emsam is unimpressive in comparison, as far as I can tell, and is highly expensive.
poster:ed_uk2010
thread:1075467
URL: http://www.dr-bob.org/babble/20150102/msgs/1075469.html