Posted by jono_in_adelaide on December 10, 2012, at 16:41:09
In reply to Re: Augment Effexor or TCS or MAOI or other? » jono_in_adelaide, posted by SLS on December 9, 2012, at 23:28:56
"Why do you say this?"
Because desipramine hits noradrenalin much harder than effexor, and antidepressants acting on noradrenalin are generaly better against dysthymic symptoms than ones actingmainly on seretonic (eg standard doses of Effexor)
Effexor only has a clinicaly significant effect on NA at doses of 300mg a day, which few patients ever reach, at doses of 75-150mg 9the ones commonly prescribed) it isnt clinicaly superior to Zoloft or Lexapro.
The reason I suggested Zoloft/Lexapro + desipramine instead of Effexor + desipramine is cost effectiveness, there isnt a down side to taking Effexor instead of an SSRI, but there inst realy an upside, and the cost is significantly more.
poster:jono_in_adelaide
thread:1032720
URL: http://www.dr-bob.org/babble/20121130/msgs/1032768.html