Posted by SLS on February 8, 2012, at 10:20:34
In reply to Re: Adding Parnate and prazosin. » SLS, posted by ed_uk2010 on February 8, 2012, at 6:44:30
> >TCA = Potent NE alpha-1a; NE alpha-1d
> >TCA = Weak NE alpha-1b
> >
> > My guess is that TCA does not effectively antagonize enough brain NE alpha-1b receptors to modulate brain monoaminergic neurotransmission. It just doesn't hit the right spots. NE alpha-1b receptors are known to be impaired in depression.> If 1b receptors are known to be impaired in depression, would blocking them be a good thing?
I don't know.
It would probably depend upon the function of the circuits that the NE alpha-1b receptor-innervated neurons modulate.
> Perhaps 1b antagonists are useful in PTSD but not depressive illness?
I have depression (probably bipolar). For me, prazosin is making a significant improvement in depression. It "feels" like a potent and clean antidepressant rather than an anxiolytic. It might depend on what were the psychosocial inducers of the depression. If abuse or neglect were conditions extant during childhood, prazosin might work specifically for the type of depression that results. Who knows? Maybe its antidepressant effects are more generalized. That would be nice. The question is: What are the antidepressants that prazosin best augments.
> In clinical trials, prazosin often causes a lack of energy and weakness,
Yup. These are well known side effects seen in general usage. They generally dissipate over time. I experienced these side effects during the first two or three weeks. They have disappeared completely. Unfortunately, prazosin can also reduce sex-drive, although it is now returning to some degree.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1005781
URL: http://www.dr-bob.org/babble/20120202/msgs/1009660.html