Posted by ed_uk2010 on February 8, 2012, at 6:44:30
In reply to Re: Adding Parnate and prazosin. » ed_uk2010, posted by SLS on February 7, 2012, at 13:01:27
>TCA = Potent NE alpha-1a; NE alpha-1d
>TCA = Weak NE alpha-1b
>
> My guess is that TCA does not effectively antagonize enough brain NE alpha-1b receptors to modulate brain monoaminergic neurotransmission. It just doesn't hit the right spots. NE alpha-1b receptors are known to be impaired in depression.If 1b receptors are known to be impaired in depression, would blocking them be a good thing? Perhaps 1b antagonists are useful in PTSD but not depressive illness? In clinical trials, prazosin often causes a lack of energy and weakness, and less commonly depressive symptoms and nervousness.
poster:ed_uk2010
thread:1005781
URL: http://www.dr-bob.org/babble/20120202/msgs/1009645.html