Posted by SLS on February 7, 2012, at 16:04:56
In reply to Re: Adding Parnate and prazosin., posted by SLS on February 7, 2012, at 13:14:14
PTSD and the amygdala:
http://www.ptsd.va.gov/professional/pages/pharmacological-treatment-acute-stress.asp
"In PTSD, the normal checks and balances on amygdala activation have been impaired, so that the restraining influence on the amygdala of the medial prefrontal cortex (PFC, especially the anterior cingulate gyrus and orbitofrontal cortex) is severely disrupted (2,3). Disinhibition of the amygdala produces a vicious spiral of recurrent fear conditioning, in which ambiguous stimuli are more likely to be appraised as threatening; mechanisms for extinguishing such responses are nullified; and key limbic nuclei are sensitized, thereby lowering the threshold for fearful reactivity (2, 4-6)"
Perhaps prazosin would compensate for the PTSD-induced sensitization and thereby reduce anxiety.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.- George Bernard Shaw
poster:SLS
thread:1005781
URL: http://www.dr-bob.org/babble/20120202/msgs/1009584.html