Posted by CaptainAmerica1967 on October 23, 2011, at 10:53:40
In reply to Re: opiates and major depression - Question, posted by uncouth on October 23, 2011, at 8:56:58
The biology or mechanism of action of bup being the longest and most potent kappa antagonist that has an blocking effect on the overactivity of the brain and seems to calm it down do to chronic stress. The prefrontal cortex and the limbic system, the nucleus accumbens is part of the pleasure center(dopamine)and seems to not be normal (overactive) in both addicted patient and depressed patients according to Richard Gracer, MD of The National Alliance Of Advocates For Buprenorphine Treatment or NAABT.org. I've heard that kappa antagonist also block dynorphin which is the opposite of endorphins and makes individual feel kind of lousy, and not euphoric. I personally feel buprenorphine has more anti-anxiety effect that any of the benzodiazepines.
So much of this was already covered in the below post that I will repost them; hopefully that's allowed here.
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keeping opioid prescribers out of trouble pseudoname 11/10/05
Re: opiates and major depression Nieko 7/19/08
Re: keeping opioid prescribers out of trouble Crotale 7/21/08
Re: opiates and major depression » androog maree 7/22/08
Re: opiates and major depression Crotale 7/25/08
Re: opiates and major depression Crotale 7/25/08
Re: opiates and major depression » maree Nieko 8/27/08
Re: opiates and major depression » Aurora safire4hope 10/18/11
Re: opiates and major depression » safire4hope Chairman_MAO 10/18/11
Re: opiates and major depression » Chairman_MAO safire4hope 10/18/11
Re: opiates and major depression » safire4hope Chairman_MAO 10/18/11
Re: opiates and major depression » safire4hope CaptainAmerica1967 10/18/11
Re: opiates and major depression » Chairman_MAO safire4hope 10/18/11
Re: opiates and major depression » CaptainAmerica1967 Chairman_MAO 10/18/11
Re: opiates and major depression sigismund 10/19/11
Re: opiates and major depression » Chairman_MAO CaptainAmerica1967 10/19/11
Re: opiates and major depression » Chairman_MAO europerep 10/19/11
Re: opiates and major depression » europerep Chairman_MAO 10/19/11
Re: opiates and major depression » CaptainAmerica1967 Chairman_MAO 10/19/11
Re: opiates and major depression » CaptainAmerica1967 safire4hope 10/19/11
Re: opiates and major depression » Chairman_MAO europerep 10/20/11
Re: opiates and major depression CaptainAmerica1967 10/20/11
Re: opiates and major depression » CaptainAmerica1967 SLS 10/20/11
Re: opiates and major depression JohnLA 10/20/11
Re: opiates and major depression CaptainAmerica1967 10/21/11
Re: opiates and major depression - Question uncouth 10/23/11
poster:CaptainAmerica1967
thread:81414
URL: http://www.dr-bob.org/babble/20111016/msgs/1000595.html