Posted by Bob on September 17, 2011, at 20:20:11
In reply to Re: BDNF connection?, posted by linkadge on September 17, 2011, at 16:24:00
> The BDNF thing is far from conclusive. Some studies conclude that BDNF signalling is actually elevated in depression:
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> "Research suggests that aberrant signaling by a chemical called Brain-Derived Neurotrophic Factor (BDNF) through its receptor TrkB, may contribute to anxiety and depression, and inhibiting this pathway in mice can reduce anxiety and depression-related behaviors. "
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> http://news.drugs-expert.com/depression-news/researchers-identify-trkb-antagonist-with-anxiolytic-antidepressant-activity/
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Well that's one thing I certainly agree with... they definitely have very little idea what's going on. As I look back over the course of my illness, I can see that in the beginning treatments gave me some hope, but as the years ticked by there was less and less response and more and more sickness. Most things didn't work at all, and those that "worked" did only for a short time. I am now a shadow of my former self, even on "good days". As for the bad days - those are the ones where I really don't think I'm gonna make it.
> BDNF may indirectly be influenced by antidepressant treatments. For instance, a metabolite of serotonin n-acetyl-serotonin is a potent trk-b agonist. This is the same receptor that BDNF activates. Also the antidepressant amitriptyline is a direct trk-b agonist.
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> But, I don't think they've got a clue whats going on, because all of the findings are contradictory.
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> Linkadge
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poster:Bob
thread:997028
URL: http://www.dr-bob.org/babble/20110914/msgs/997046.html