Posted by linkadge on September 17, 2011, at 16:24:00
In reply to BDNF connection?, posted by Bob on September 17, 2011, at 16:01:06
The BDNF thing is far from conclusive. Some studies conclude that BDNF signalling is actually elevated in depression:
"Research suggests that aberrant signaling by a chemical called Brain-Derived Neurotrophic Factor (BDNF) through its receptor TrkB, may contribute to anxiety and depression, and inhibiting this pathway in mice can reduce anxiety and depression-related behaviors. "
BDNF may indirectly be influenced by antidepressant treatments. For instance, a metabolite of serotonin n-acetyl-serotonin is a potent trk-b agonist. This is the same receptor that BDNF activates. Also the antidepressant amitriptyline is a direct trk-b agonist.
But, I don't think they've got a clue whats going on, because all of the findings are contradictory.
Linkadge
poster:linkadge
thread:997028
URL: http://www.dr-bob.org/babble/20110914/msgs/997031.html