Posted by SLS on December 19, 2010, at 19:41:25
In reply to Re: Normal sleep » SLS, posted by linkadge on December 18, 2010, at 7:49:16
Hi Linkadge.
> >However, if one removes the 5-HT2c receptor >antagonism pharmacologically, the antidepressant >effect disappears. Both melatonergic and >serotonergic manipulation are necessary for >Valdoxan to produce a therapeutic response.
>
> Personally, I think this assertion could be a bit biased. Of course the makers of valdoxan want to establish that their medication has some key property that cannot be replicated by OTC melatonin.
>
> Linkadge
Agomelatine (Valdoxan) has been shown to stimulate melatonin M1 and M2 receptors, and to block serotonin 5-HT2c receptors.In a rather elegant experiment, depressed subjects were treated with agomelatine. For those who responded favorably to the drug, two experiments were conducted while the subjects were in a euthymic state. Using various neurochemical probes, it was reported that the antidepressant response to agomelatine disappeared with the addition of melatonin M1 and M2 receptor antagonists. Additionally, the antidepressant effect of the drug disappeared with the addition of serotonin 5-HT2c receptor agonists. These results suggest that melatonin agonism and serotonin 5-HT2c antagonism are both necessary for agomelatine to exert its antidepressant effect.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:973562
URL: http://www.dr-bob.org/babble/20101218/msgs/974038.html