Posted by SLS on December 15, 2010, at 4:54:29
In reply to Re: Normal sleep » linkadge, posted by medamorphosis on December 15, 2010, at 0:05:01
Hi.
> Hi mate. Know exactly how you feel. But follow my post above about Valdoxan. I will add my progress as I go, and babblemail any specifics. I like the fact it seems to 'balance' carcadian rythms from the melatonon agonist actions.
A friend of mine had been an ultra-rapid cycler and possibly bipolar II. The phase changes for him worked like clockwork such that he was able to keep a calendar of his regular cycling and plan future events around it. This had been going on for years without deviation. The addition of Valdoxan to his treatment regime completely abolished the cycle within two weeks. He has been doing well for 3 or 4 months.
There is plenty of suggestions made in the medical literature that establishes a relationship between circadian rhythms and the presentation of MDD or BD. My guess is that circadian rhythms play a more significant role in the precipitation or persistence in BD than MDD. I imagine this is indicative of the properties of lithium known to affect the cascade of events that are contributory to the regulation of circadian rhythms. The stimulation of melatonin M1 and M2 receptors have been demonstrated to be necessary for an antidepressant effect to manifest by Valdoxan. However, if one removes the 5-HT2c receptor antagonism pharmacologically, the antidepressant effect disappears. Both melatonergic and serotonergic manipulation are necessary for Valdoxan to produce a therapeutic response.
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.
poster:SLS
thread:973562
URL: http://www.dr-bob.org/babble/20101203/msgs/973619.html