Posted by medamorphosis on December 15, 2010, at 20:40:04
In reply to Re: Normal sleep » medamorphosis, posted by SLS on December 15, 2010, at 4:54:29
> Hi.
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> > Hi mate. Know exactly how you feel. But follow my post above about Valdoxan. I will add my progress as I go, and babblemail any specifics. I like the fact it seems to 'balance' carcadian rythms from the melatonon agonist actions.
>
> A friend of mine had been an ultra-rapid cycler and possibly bipolar II. The phase changes for him worked like clockwork such that he was able to keep a calendar of his regular cycling and plan future events around it. This had been going on for years without deviation. The addition of Valdoxan to his treatment regime completely abolished the cycle within two weeks. He has been doing well for 3 or 4 months.
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> There is plenty of suggestions made in the medical literature that establishes a relationship between circadian rhythms and the presentation of MDD or BD. My guess is that circadian rhythms play a more significant role in the precipitation or persistence in BD than MDD. I imagine this is indicative of the properties of lithium known to affect the cascade of events that are contributory to the regulation of circadian rhythms. The stimulation of melatonin M1 and M2 receptors have been demonstrated to be necessary for an antidepressant effect to manifest by Valdoxan. However, if one removes the 5-HT2c receptor antagonism pharmacologically, the antidepressant effect disappears. Both melatonergic and serotonergic manipulation are necessary for Valdoxan to produce a therapeutic response.
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> - ScottJeez you know ur stuff! As many others do on this sight. Glad I came back :)
U.K.resedent
Ills: AvPD, major depression, addictive personality
Regime: 80mg isocarboxazid, 4mg clonazepam, 25mg Valdoxan, hi-dose b vits + zinc
poster:medamorphosis
thread:973562
URL: http://www.dr-bob.org/babble/20101203/msgs/973661.html