Posted by SLS on May 29, 2010, at 6:03:39
In reply to Re: Seroquel and AcH? » SLS, posted by Bob on May 29, 2010, at 0:06:04
> > > Does Seroquel have anticholinergic side effects? It says in the Wikipedia entry that its effects on the acetylcholine system is "controversial".
> >
> > After reviewing the literature I found on Google, I can see why there would be controversy. There are quite a few conflicting reports and opinions. I still think that much of what is described as being anticholinergic with quetiapine is actually noradrenergic.
> >
> >
> > - Scott
>
>
> That's kinda scary. I thought that at least the scientific community was relatively sure about receptor activity of drugs, at least the receptors we're aware about.One database of ligand affinities to specific receptors reports that Seroquel has some weak to moderate ACh muscarinic M1 binding. However, its potency at this receptor is roughly the same as its potency at D2 and 5-HT2a receptors. This might indicate that at the high dosages used for schizophrenia, some anticholinergic side effects appear. These would be potentiated by norepeneprine reuptake inhibition.
- ScottThe measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:949197
URL: http://www.dr-bob.org/babble/20100524/msgs/949366.html