Posted by SLS on May 28, 2010, at 17:06:33
In reply to Re: Seroquel and AcH? » SLS, posted by Bob on May 28, 2010, at 16:40:44
> > > Does Seroquel have anticholinergic side effects? It says in the Wikipedia entry that its effects on the acetylcholine system is "controversial".
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> > According to one source, quetiapine (Seroquel) produces almost no anticholinergic (muscarinic) receptor binding. However, there was no information regarding norquetiapine, a major active metabolite. I wonder if there is some confusion with the noradrenergic effects of norquetiapine with the effects that are described as being anticholinergic. They might appear similar as they both bias the autonomic system balance in the same direction. It would be good to know what anticholinergic effects are described in the controversy.
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> > - Scott
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> I saw someone mention dry mouth in another posting, and of course there is the fatigue thing. But I'm not sure what actual effects they were referring to in the article.Dry mouth (xerostomia) can be a side effect of Strattera (atomoxetine), a selective NE reuptake inhibitor with virtually no anticholinergic activity. It is possible that the dry mouth reported for Seroquel is actually due to the NE reuptake inhibition exhibited by norquetiapine. I doubt Seroquel is anticholinergic.
- ScottThe measure of achievement lies not in how high the mountain,
but in how hard the climb.The measure of success lies only in how high one feels he must
climb to get there.
poster:SLS
thread:949197
URL: http://www.dr-bob.org/babble/20100524/msgs/949301.html