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Re: Seroquel and AcH?

Posted by SLS on May 28, 2010, at 7:12:16

In reply to Seroquel and AcH?, posted by Bob on May 27, 2010, at 23:07:30

> Does Seroquel have anticholinergic side effects? It says in the Wikipedia entry that its effects on the acetylcholine system is "controversial".

According to one source, quetiapine (Seroquel) produces almost no anticholinergic (muscarinic) receptor binding. However, there was no information regarding norquetiapine, a major active metabolite. I wonder if there is some confusion with the noradrenergic effects of norquetiapine with the effects that are described as being anticholinergic. They might appear similar as they both bias the autonomic system balance in the same direction. It would be good to know what anticholinergic effects are described in the controversy.


- Scott


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