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Re: Parnate losing effectiveness. Why?? Help please. » Girlnterrupted78

Posted by SLS on October 30, 2009, at 6:47:28

In reply to Re: Parnate losing effectiveness. Why?? Help please. » SLS, posted by Girlnterrupted78 on October 29, 2009, at 18:02:13

To be conservative, you should give each dosage adjustment three weeks to work. It might not be a valid gauge for prognosis to evaluate how a dosage adjustment affects you within the first few days.

I have taken 150mg of Parnate and combined it with 200mg of desipramine and 20mg of amphetamine. I did not respond much better at this high dosage of Parnate than I did at lower dosages. However, I really should have been taking 300mg of desipramine.

I would consider adding an adjunct drug after three weeks at 80mg of Parnate before going with a high-dose strategy.

You are going to receive a variety of opinions as to what to do next. I can't be sure that high-dose Parnate wouldn't work. It is definitely effective for some people, but I am dubious that the percentage of responders is that high of those people who do not respond to lower dosages. I have read the works of Jay Amsterdam, MD and Andrew Nierenberg, MD regarding high-dose Parnate therapy. Neither doctor seems to have followed up by embracing this treatment strategy such that they include it in their treatment algorithms.


- Scott

 

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