Posted by SLS on May 2, 2009, at 15:28:35
In reply to Re: OCD - Just a thought., posted by linkadge on May 2, 2009, at 15:15:13
> I wouldn't personally use risperidal for OCD. Infact OCD can be a side effect of risperidal.
>
> My mother developed an intense OCD like reaction to risperidal usage.
>
> There are some studies suggesting seroquel can augment SSRI's for OCD. Perhaps norquetiapine has some efficacy here.
You could be right about risperidone. Perhaps it is not the ideal choice as an augmenter. I had thought that its stronger binding to DA receptors would be useful. I am not very knowledgeable in this area - or perhaps any area.
- Scott
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1: Eur Neuropsychopharmacol. 2008 May;18(5):364-72. Epub 2008 Feb 15.Click here to read Links
8-week, single-blind, randomized trial comparing risperidone versus olanzapine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder.
Maina G, Pessina E, Albert U, Bogetto F.Department of Neurosciences, Mood and Anxiety Disorders Unit, University of Turin, Italy. giuseppemaina@hotmail.com
The aim of the present pilot study was to investigate in a single-blind manner, over a period of 8 weeks, the comparative efficacy and tolerability of risperidone versus olanzapine addition in the treatment of OCD patients who did not show a >or=35% decrease in the YBOCS score after 16-week SRI treatment (defined as resistant). The study consisted of two different phases: a 16-week open-label prospective phase to ascertain resistance to SRI treatment and an 8-week single-blind addition phase for resistant subjects only. Ninety-six subjects with DSM-IV OCD (YBOCS>or=16) entered the open-label prospective phase; at the end of the 16-week period, 50 (52%) were judged to be resistant and were randomized to receive risperidone (1 to 3 mg/d) or olanzapine (2.5 to 10 mg/d) addition for 8 weeks. Overall, patients in both groups responded significantly, without differences between the two treatment groups; although no differences emerged for the proportion of patients reporting at least an adverse event, the profiles of adverse experiences differed significantly, being risperidone associated with amenorrhoea and olanzapine with weight gain.
poster:SLS
thread:893777
URL: http://www.dr-bob.org/babble/20090426/msgs/893898.html