Posted by linkadge on May 2, 2009, at 15:12:32
In reply to Re: OCD - Just a thought., posted by SLS on May 2, 2009, at 8:01:36
There is little evidence that OCD is a biochemical disorder as research has not conclusively shown the existence of biochemical abnormalities.
There is some evidence that there is a deficit of grey matter within the OCD circuit (orbitofrontal cortex, the caudate nucleus, and the thalamus). This may be what is resulting in the relative inability to properly process and filter anxiety.
The SSRI's kind of put the breaks on this circuit perhaps by altering the ballance of monoamines in this region.
Another thing to keep in mind is that clomipramine has some dopamine and acetylcholine antagonism which may also reduce glutamatergic function in the frontal cortex.
Shame about its carcinogenic potential. It was a darn good psychotropic.
Linkadge
poster:linkadge
thread:893777
URL: http://www.dr-bob.org/babble/20090426/msgs/893895.html