Posted by SLS on April 25, 2009, at 5:31:41
In reply to Re: Abilify and Luvox - dangerous interaction, posted by samantha28 on April 24, 2009, at 22:19:58
> Hi Larry, thanks so much for your reply. When you say that the Fluvoxamine will inhibit the metabolism of aripiprazole does that mean it will make the aripipazole less effective and stop working? Does it mean I have to take more aripipazole?
>
> I have bipolar disorder and I shouldn't be taking antidepressants alone. I am also having a little bit of shortness or breath.
>
> cheers
>
> Sam
>
> > > Hi, I am currently on 20mg of Abilify and recently started on 100mg of luvox and I feel dizzy, shakey, sleepy and blurred vision.
> > >
> > > Are this normal side effects or are these drugs contraindicated?
> > >
> > > Cheers
> > >
> > > Sam
> >
> > Yes, there's a definite interaction. Fluvoxamine will inhibit the metabolism of aripiprazole. It's as if you took more Abilify than you normally do, along with the effects of the Luvox. And I haven't considered the receptor-based interactions.
> >
> > If you can't tolerate the combination, it's contra-indicated.
If Luvox inhibits the metabolism (slows down the disassembly) of Abilify, the blood levels of Abilify will increase.I have not researched the interaction, so I will defer to Larry Hoover for his expertise in this area.
- Scott
poster:SLS
thread:892639
URL: http://www.dr-bob.org/babble/20090416/msgs/892695.html