Posted by myco on March 4, 2009, at 13:30:13
In reply to Re: Survey: Does green tea lessen your symptoms? » desolationrower, posted by myco on March 4, 2009, at 13:26:23
Do you of any natural source dopamine B-hydroxlase inhibitors d/r? I'm having fun playing alchemist here...actually considering going back to school and into something involving biochem/pharm...hella interesting stuff
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> This is the idea I was getting at d/r but...
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> I wasn't aware it inhibits COMT. I thought it acts as an inhibitor of aromatic L-amino acid decarboxylases (AADC)...such as DOPA decarboxylase that metabolizes dopamine from L-dopa. My thinking is that by inhibiting this, with or without the supplementation of L-dopa, one could increase the effects of L-dopa in the brain (although not quite sure what that would do exactly in terms of anxiety and dep lol, i'm just toying with ideas). Also AADC's metabolize seratonin also don't they? Thats why administration of L-dopa (with cofactor vit B6) without an inhibitor like green tea will lead to decrease in seratonin won't it?...using up the AADC which is "rate limiting"? Therefor some naturopaths recommend coadministration of a precurser to seratonin like 5-htp in addition to a L-dopa supplement I think.
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> > It depends on which kind of free radical they are measured against. However the imporant thing about antidoxidants isn't actually ability to neutralize radicals (except for some cases, like alcohol damange to GI track i think is one example). but the antioxidant chemicals tend to have various beneficial actions. which is why its good to get a variety in the diet of them, but also why some such as green tea as expecially encouraged.
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> > the other thing green tea does is inhibit the COMT enzyme, which metabolizes NA amoung other things (similar to MAO). this is how green tea raises metabolism, but theoretically could increase anxieyt.
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> > -d/r
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poster:myco
thread:883607
URL: http://www.dr-bob.org/babble/20090304/msgs/883737.html