Posted by Vincent_QC on December 7, 2008, at 7:38:29
In reply to Re: Nardil + Insomnia - Re to 'ParnateStarted2008', posted by desolationrower on December 6, 2008, at 15:37:07
> Some of hte benefit of phenelzine & gaba transaminase might be with the gabab receptors, which aren't affected by benzos.
>
> -d/rBenzo work with the gaba receptors...no gaba receptors on the neurons, no calm effect!!!
I think you never take the time to read the Dr. Ashton book about the action of the benzos and how they work on the brains???
The Ashton doctor do a lot or research on the subject:
"The way in which GABA sends its inhibitory message is by a clever electronic device. Its reaction with special sites (GABA-receptors) on the outside of the receiving neuron opens a channel, allowing negatively charged particles (chloride ions) to pass to the inside of the neuron. These negative ions "supercharge" the neuron making it less responsive to other neurotransmitters which would normally excite it. Benzodiazepines also react at their own special sites (benzodiazepine receptors), situated actually on the GABA-receptor. Combination of a benzodiazepine at this site acts as a booster to the actions of GABA, allowing more chloride ions to enter the neuron, making it even more resistant to excitation. Various subtypes of benzodiazepine receptors have slightly different actions. One subtype (alpha 1) is responsible for sedative effects, another (alpha 2) for anti-anxiety effects, and both alpha 1 and alpha 2, as well as alpha 5, for anticonvulsant effects. All benzodiazepines combine, to a greater or lesser extent, with all these subtypes and all enhance GABA activity in the brain.
As a consequence of the enhancement of GABA's inhibitory activity caused by benzodiazepines, the brain's output of excitatory neurotransmitters, including norepinephrine (noradrenaline), serotonin, acetyl choline and dopamine, is reduced. Such excitatory neurotransmitters are necessary for normal alertness, memory, muscle tone and co-ordination, emotional responses, endocrine gland secretions, heart rate and blood pressure control and a host of other functions, all of which may be impaired by benzodiazepines. Other benzodiazepine receptors, not linked to GABA, are present in the kidney, colon, blood cells and adrenal cortex and these may also be affected by some benzodiazepines. These direct and indirect actions are responsible for the well-known adverse effects of dosage with benzodiazepines."
The processus with the Nardil gaba effect and the Benzo gaba effect is not very different but is less powerfull. Nardil elevates brain levels of gamma-aminobutyric acid (GABA)...So more Gaba in the brain, mean more anxiolytic and calm effect of the person...but Nardil don't blok the ion channel like the Dr. Ashton explain...so it's why it's less potent and addictive...Nardil or others anticonvulsives drugs seem to not change the structure of the neurons, especially the gaba sites on the neurons...but the benzo drugs and all the ZZZ drugs to sleep do it and boost the normal processus of the gaba actions on the neurons and also the gaba site receptors on the neurons...this action seem to kill the gaba receptors, so you need more and more benzo drugs to reach good neurons with good gaba sites alive to absorb them...And it's a never ending circle...Some Doctors think that's impossible that the benzo drugs destroy the gaba receptors on a neurons...even is you abuse them, but others said that too much gaba in the brains make a change in the structure ot the neurons and the gaba recptors on the neurons just stop answering to the gaba message...
The same thing apply with the anticonvulsive drugs like Gabapentin, Lyrica, Neurontin...they all do the kind of effect that do the Nardil on the Gaba...it's probably why they are often prescribe with regular IRSS...to encheance the gaba effects on the neurons... But that processus don't work with everyone, and peoples who take benzo drugs for a long time seem to not response at all at this new kinds of anticonvulsives drugs.
Like I always say, too much is not necessary more good!!!... I'm not against the benzo drug, for now I take more than 8mg/ativa by day and also my valiums pills 20 mg...i'm not suppose but I feel really overstress...but I know that I Will have another month or more of bad side effects and cognitives problems when I will stop the Ativan pills...i'm like that...If I give too much benzo to my brains, the seems to lost their heads!!! hahaha
A good likn about the benzo :
poster:Vincent_QC
thread:866860
URL: http://www.dr-bob.org/babble/20081204/msgs/867204.html