Posted by bleauberry on November 28, 2008, at 9:07:33
In reply to Different treatment for emotional numbness???, posted by X_ander on November 27, 2008, at 20:54:27
Based on my own experience I think there could be some truth to the opioid connection. I was on LDN (low dose Naltrexone) for only a short time and will probably revisit it soon. During that short time, I noticed more interest in things I was doing, more especially with things that I try to enjoy and I know I do enjoy (except I don't feel the joy). Such as guitar playing. I played a ton of guitar on LDN and was "into it".
It wasn't a miraculous awakening kind of thing, but rather a situation where if you force yourself to start doing something, in a little while you are actually enjoying it. This was from just 1.5mg taken at 9pm nightly.
While LDN supposedly only blocks opioid receptors during the blood level spike a few hours after dosing, my own feeling was that it blocked them about 16 hours.
There is the possibility also that opioid antagonists have a direct or downstream indirect effect of stimulating dopamine function. It just instinctively felt that way to me.
poster:bleauberry
thread:865523
URL: http://www.dr-bob.org/babble/20081123/msgs/865563.html